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Daniel J. M. Crouch, Walter F. Bodmer. Evolution by Natural Selection is a scientific law and not just a theory. Academia Biology (2024).
Goutham Atla, Silvia Bonàs-Guarch, Mirabai Cuenca-Ardura, Anthony Beucher, Daniel JM Crouch, Javier Garcia-Hurtado, Ignasi Moran, Manuel Irimia, Rashmi B Prasad, Anna L Gloyn, Lorella Marselli, Mara Suleiman, Thierry Berney, Eelco JP de Koning, Julie Kerr-Conte, Francois Pattou, John A Todd, Lorenzo Piemonti, Jorge Ferrer. Genetic regulation of RNA splicing in human pancreatic islets. Genome Biology (2022).
Daniel J. M. Crouch, Jamie R.J. Inshaw, Catherine C. Robertson, Jia-Yuan Zhang, Wei-Min Chen, Suna Onengut-Gumuscu, Antony J. Cutler, Carlo Sidore, Francesco Cucca, Flemming Pociot, Patrick Concannon, Stephen S. Rich, John A. Todd. Enhanced genetic analysis of type 1 diabetes by selecting variants on both effect size and significance, and by integration with autoimmune thyroid disease. bioRxiv (2022).
Tom G Richardson, Daniel JM Crouch, Grace M Power, Fernanda Morales-Berstein, Emma Hazelwood, Si Fang, Yoonsu Cho, Jamie RJ Inshaw, Catherine C Robertson, Carlo Sidore, Francesco Cucca, Steven S Rich, John A Todd, George Davey Smith. Childhood body size directly increases type 1 diabetes risk based on a lifecourse Mendelian randomization approach. Nature Communications (2022).
Catherine C Robertson, Jamie RJ Inshaw, Suna Onengut-Gumuscu, Wei-Min Chen, David Flores Santa Cruz, Hanzhi Yang, Antony J Cutler, Daniel JM Crouch, Emily Farber, S Louis Bridges, Jeffrey C Edberg, Robert P Kimberly, Jane H Buckner, Panos Deloukas, Jasmin Divers, Dana Dabelea, Jean M Lawrence, Santica Marcovina, Amy S Shah, Carla J Greenbaum, Mark A Atkinson, Peter K Gregersen, Jorge R Oksenberg, Flemming Pociot, Marian J Rewers, Andrea K Steck, David B Dunger, Linda S Wicker, Patrick Concannon, John A Todd, Stephen S Rich. Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes. Nature Genetics (2021).
Walter F. Bodmer, Daniel J.M. Crouch. Evolutionary perspectives
on cancer and aging. Book chapter from New Horizons in Evolution (2021).
Jamie RJ Inshaw, Carlo Sidore, Francesco Cucca, M Irina Stefana, Daniel JM Crouch, Mark I McCarthy, Anubha Mahajan, John A Todd. Analysis of overlapping genetic association in type 1 and type 2 diabetes. Diabetologia (2021).
Daniel J.M. Crouch, Walter F. Bodmer. Polygenic inheritance, GWAS,
Polygenic Risk Scores and the search for functional variants. PNAS (2020).
Walter F. Bodmer and Daniel J.M. Crouch. Somatic selection of poorly differentiating variant stem cell clones could be a key to human ageing. Journal of Theoretical Biology (2020, bioRxiv 2019) (Postprint).
JRJ Inshaw, AJ Cutler, DJM Crouch, LS Wicker, JA Todd. Genetic variants predisposing most strongly to type 1 diabetes diagnosed under age 7 years lie near candidate genes that function in the immune system and in pancreatic beta cells. Diabetes Care (2020, bioRxiv 2019). (Preprint)
Ricardo Ferreira, Xaquin Castro Dopico, Joao Oliveira, Daniel Rainbow, Jennie Hsiu Mien Yang,
Sarah Todd, Mhairi McNeill, Maristella Steri, Valeria Orru, Edoardo Fiorillo, Daniel Crouch,
Marcin Pekalski, Francesco Cucca, Timothy Ian Martin Tree, Timothy Vyse, Linda Wicker, John
Todd. Chronic immune activation in systemic lupus erythematosus and the autoimmune PTPN22 Trp620 risk allele drive the expansion of FOXP3+ regulatory T cells and PD-1 expression. Frontiers in Immunology (2019).
Daniel J.M. Crouch, Bruce Winney, Willem P. Koppen, William J. Christmas, Katarzyna Hutnik, Tammy Day, Devendra Meena, Abdelhamid Boumertit, Pirro Hysi, Ayrun Nessa, Tim D. Spector, Josef Kittler, Walter F. Bodmer. Genetics of the human face: identification of large effect single gene variants. (open access) PNAS (2018, bioRxiv 2017). (Postprint)
Daniel J.M. Crouch. Statistical aspects of natural selection, with implications for the evolution of sexual reproduction (restricted access). Journal of Theoretical Biology (2017). (Postprint). This updated postprint features a correction in Appendix B.
W.P. Koppen, W.J. Christmas, D.J.M. Crouch, W.F. Bodmer and J.V. Kittler. Extending Non-negative Matrix Factorisation to 3D Registered Data (restricted access). International Conference on Biometrics (2016).
Jane M Yarnall, Daniel J M Crouch, Cathryn M Lewis. Incorporating non-genetic risk factors and behavioural modifications into risk prediction models for colorectal cancer (restricted access). Cancer Epidemiology (2013).
Daniel J M Crouch, Graham H M Goddard, Cathryn M Lewis. REGENT: a risk assessment and classification algorithm for genetic and environmental factors. European Journal of Human Genetics (2013).
Daniel J M Crouch and Michael E Weale. Inferring separate parental admixture components in unknown DNA samples using autosomal SNPs. European Journal of Human Genetics (2012).
Colm O'Dushlaine, Ruth McQuillan, Michael E Weale, Daniel J M Crouch, Asa Johansson, Yurii Aulchenko, Christopher S Franklin, Ozren Polašek, Christian Fuchsberger, Aiden Corvin, Andrew A Hicks, Veronique Vitart, Caroline Hayward, Sarah H Wild, Thomas Meitinger, Cornelia M van Duijn, Ulf Gyllensten, Alan F Wright, Harry Campbell, Peter P Pramstaller, Igor Rudan and James F Wilson. Genes predict village of origin in rural Europe. European Journal of Human Genetics (2010).